Cells Persistently Infected with Newcastle Disease Virus
نویسندگان
چکیده
منابع مشابه
Effect of exogenous interferon on L cells persistently infected with Newcastle disease virus.
Prolonged treatment with relatively high concentrations of interferon was required to "cure" L cells persistently infected with Newcastle disease virus.
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Evidence is presented which confirms that temperature-sensitive (ts) mutants with an RNA- phenotype are spontaneously selected in persistent infection of cell lines with Newcastle disease virus. Persistently infected BHK-21 cells, maintained since 1973, produce no interferon and are completely susceptible to vesicular stomatitis virus. Persistent infection of a canine kidney cell line (MDCK) te...
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Newcastle Disease Virus (NDV) is an RNA virus, which infects several tumor cells and shows cellular toxicity towards them. The antitumor activity of NDV has been reported in several tumors. In this study, we evaluated the antitumor effect of a NDV-infected melanoma cell vaccine on lung metastasis based on tumor-specific immune responses in a mouse model. B16 mouse melanoma cells were infected w...
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The ability of NDV-infected HeLa cells to synthesize DNA, protein, and RNA was investigated by measuring the incorporation of tritiated precursors into these substances at intervals after infection of cells with a virus/cell multiplicity of 500:1. A significant decrease in incorporation of precursors into DNA and protein was first observed at 3(1/4) hours after infection. By 4(1/2) hours, an 80...
متن کاملDelay in the incorporation of protein into virus nucleocapsid in Newcastle disease virus infected cells.
In cells infected with paramyxovirus progeny 50 S RNA seems to be incorporated immediately into the nucleocapsid (Blair & Robinson, I97o). There has been no report of any attempt to estimate the time interval between the synthesis of a molecule of nucleocapsid protein and its incorporation into the structure of the nucleocapsid. In the experiments described in this paper the problem has been ap...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1970
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.6.1.42-48.1970